Fig. 5

A The TEM image of DAR and its pH-triggered structure transition B The temperature elevation of DAR, PBS, IR820 and cDAR after laser irradiation. (left) and Infrared thermographic images of mice injected with saline, IR820 and DAR were tested at 5 min after laser irradiation (right). C The lysosome escape of DAR in MCF7 cells. Scale bar was 20 μm(left) and the lysosome distribution of ROS that produced DAR + laser treatment. Scale bar was 30 μm (right). D The MCF7(left) / 4 T1(right) tumor weight and tumor inhibition rate of different groups (n = 5). ⁎⁎p < 0.01 vs. control, ##p < 0.01 vs. DAR + laser + Desferal®; The percent of CD8 + IFNγ + T cells in tumor after different treatment (n = 3). ⁎⁎p < 0.01 vs. control, ##p < 0.01 vs. DAR + laser + CA.