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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1

Fig. 3

Molecular functions of proteins and microRNAs present in MSC-EVs. A Analysis of global proteomic content of MSC-EVs with focus on molecular functions by DAVID functional annotation bioinformatics microarray analysis. The analysis was conducted on proteins which were identified at least in 2 out of 3 MSC-EV samples based on 2 or more unique peptides. On the graph were displayed the most significant groups of proteins containing at least 20 proteins in terms. P < 0.05, Benjamini test < 0.05, Fisher Exact test < 0.05, (*) FDR < 0.05. B Heat-map generated with DIANA mirPath web tool showing functional pathways insertion for the most enriched miRNAs in MSC-EVs when compared to parental MSCs (fold change in expression ≥ 2.0). The attached dendrograms show hierarchical clustering results for miRNAs (Y-axis) and pathways (X-axis). Red squares indicate lower P values (more significant) and higher interaction of each miRNA with specific molecular pathway. P < 0.05

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Journal of Nanobiotechnology

ISSN: 1477-3155

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