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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1

Fig. 7

Activation of angiogenesis related pathways in skeletal muscles after MSC-EV treatment in vivo. Quantification of NO A and O2− B production in skeletal muscles by EPR. C (Left) Representative Western immunoblotting analysis of protein levels of eNOS, VEGF, Akt and their phosphorylated variants, caveolin and β-actin proteins in muscle tissues from ischemic (I) and non-ischemic (N) limb. (Right/Bottom) Quantitative analysis of expression and phosphorylation of eNOS, VEGF, Akt and caveolin-1. Values are presented as a ratio of ischemic (I) to non-ischemic (N) signal amplitude/protein expression and calculated as a percent (%) of signal in control tissues form vehicle (PBS)-treated animals. Mann–Whitney test, comparison to vehicle-treated samples (*P < 0.05)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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