Fig. 8

Tumor-bearing mice treated with nanoparticles for 21 days. A Tumor weight (n = 5, *p < 0.05, ***p < 0.001, ****p < 0.0001) (B) Tumor volume (n = 5, **p < 0.01, ***p < 0.001: significantly different from the Saline group.) (C) The rate of tumor growth inhibition (n = 5, **p < 0.01, ***p < 0.001) (D) H&E staining of tumor tissues (Red arrow: nuclear looseness, scale: 100 μm) (E) TUNEL apoptosis staining (Green fluorescence: apoptosis cells, scale: 100 μm) (F) TNF-α staining of tumor tissues in each group (scale: 100 μm) (G) Relative fluorescence intensity of TNF-α (***p < 0.001, ****p < 0.0001)