Fig. 2

Minocycline microspheres release, degradation, permeation and inhibit cell migration. A Minocycline microspheres release profile. B Degradation of nHAP/PLGA over time with pH. C Fluorescent retention observation of e minocycline or MINO@PLGA in cornea (scale bar: 100 μm). D Changes in the cornea average fluorescence intensity of drug after eye drop at 0, 30, and 60 min (n = 3). E Scratch healing assay of HUVECs treated with minocycline (1 mg/mL) or MINO@PLGA (1 mg/mL). Representative images of the scratch gap were captured at 0 h and 24 h. F Effect of MINO@PLGA on viability of HUVECs