Skip to main content
Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p/PDCD4/NF-κB pathway

Fig. 3

Quercetin performed pro-osteo-/angiogenesis and anti-inflammation of PDLSCs under periodontitis microenvironment. A, B ALP staining and its quantitative results after incubation of PDLSCs with quercetin for 4 and 7 days under periodontitis microenvironment. C, D ARS staining and its quantitative results after incubation of PDLSCs with quercetin for 14 and 21 days under periodontitis microenvironment. E–G Effect of quercetin on the expression of osteogenic-related genes (OPN and RUNX-2) and angiogenic-related genes (VEGF and bFGF) of PDLSCs through qRT-PCR. H Effect of quercetin on the expression of osteogenic-related protein (OPN) and angiogenic-related protein (VEGF) of PDLSCs through immunofluorescence staining. I Schematic of the pharmacological mechanism of quercetin on PDLSCs under periodontitis microenvironment. (#p < 0.05, ##p < 0.01 and ###p < 0.001 compared to Pg.LPS (-) + Quercetin (-) group, *p < 0.05, **p < 0.01 and ***p < 0.001 compared to Pg.LPS ( +) + Quercetin (-) group; Data are represented as the mean ± SEM, n = 3)

Back to article page

Journal of Nanobiotechnology

ISSN: 1477-3155

Contact us