Fig. 8

In vivo FLI and biosafety assessment. (A) In vivo FL images of Hepa1-6 tumor-bearing mice. (B) Alterations in FL signal intensity within the tumor regions at the respective time intervals (n = 3). (C) FL images of the major organs and tumors removed from mice 72 h postinjection of MF@DiR and (D) corresponding quantitative analysis (n = 3). (E) H&E staining images of the major organs (scale bar: 200 μm). (F) Routine blood examination results from Kunming mice intravenously injected with the MF@SOR at different time points. In panels (B) and (D), the data are presented as the mean ± SD. All p values were calculated by ANOVA. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001, ns, not significant