Fig. 5

In vivo pharmacokinetics and distribution of NCG. A Pharmacokinetic curves of different NAR formulations are shown after oral administration at a dosage of 6.9 mg/kg in rats (n = 6). B Representative images and a statistical analysis of fluorescence intensity for the in vivo distribution of various nanoparticle formulations (n = 3). Data are presented as mean ± SD, ns: p > 0.05, *p < 0.05, ***p < 0.001 indicates a comparison between the two groups. C Representative distribution of Cy5 in major organs and a statistical analysis of fluorescence intensity (n = 3). Data are presented as mean ± SD, *p < 0.05 indicates a comparison between the two groups. D Statistical analysis of fluorescence intensity in duodenum, jejunum, ileum, and liver (n = 3). Data are expressed as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001 indicates a comparison between the two groups