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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: A versatile engineered extracellular vesicle platform simultaneously targeting and eliminating senescent stromal cells and tumor cells to promote tumor regression

Fig. 1

Preparation and characterization of uPA-sEVs-siSrc. (A) Schematic illustration describing the design of uPA-sEVs-siSrc. (B) Size distribution of uPA-sEVs and uPA-sEVs-siSrc measured by nanoFCM. (C) Mean particle size of iMSC-sEVs, uPA-sEVs and uPA-sEVs-siSrc measured by nanoFCM. (D) Representative TEM images of uPA-sEVs and uPA-sEVs-siSrc. Scale bar = 200 nm. (E) Western blot analysis of iMSC, iMSC-sEVs, uPA-sEVs and uPA-sEVs-siSrc. (F) siRNA loading efficiency of uPA-sEVs-siSrc determined by a microplate reader. (G) Stability of dynamic diameter of uPA-sEVs-siSrc. (H) Serum stability of free siSrc, sEVs-siSrc and uPA-sEVs-siSrc analyzed by gel electrophoresis

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Journal of Nanobiotechnology

ISSN: 1477-3155

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