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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: A versatile engineered extracellular vesicle platform simultaneously targeting and eliminating senescent stromal cells and tumor cells to promote tumor regression

Fig. 2

Targeting capability of uPA-sEVs-siSrc in vitro. (A) Representative images of proliferative and senescent HFF-1 cells incubated with DiI-labelled sEVs and uPA-sEVs-siSrc for 4 h. Scale bar = 50 μm. (B) Mean fluorescence intensities from (A). (C) Representative images of proliferative and senescent HMEC-1 cells incubated with DiI-labelled sEVs and uPA-sEVs-siSrc for 4 h. Scale bar = 50 μm. (D) Mean fluorescence intensities from (C). (E) Representative images of A549 and MDA-MB-231 cells incubated with DiI-labelled sEVs and uPA-sEVs-siSrc for 4 h. Scale bar = 50 μm. (F) Mean fluorescence intensities from (E). Data are displayed as the mean ± SD (n = 3). ***p<0.001; ****p<0.0001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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