Fig. 3

tFNAs as a delivery carrier with antibacterial activity. (A) Schematic representation of nanotheranostic DPAu/AMD synthesis. DP: DNA nanopyramid; AMD: Actinomycin D. Reprinted with permission from Ref. [59]. (B) DPAu/AMD-treated E. coli and S. aureus cells were stained with live/dead cell stain to validate the killing effect. E. coli: Escherichia coli; S. aureus: Staphylococcus aureus. Reprinted with permission from Ref. [59]. (C) tFNAs-Antibiotic Compound (TAC) improved the survival rate of severely infected mice and promoted the healing of local infections by the excellent delivery capability of tFNAs. tFNAs: tetrahedral framework nucleic acids. Reprinted with permission from Ref. [60]. (D) Confocal laser scanning microscopy images of bacterial uptake of tFNAs and TACs in MRSA at 90 min. Reprinted with permission from Ref. [60]. (E) Confocal laser scanning microscopy images of bacterial uptake of tFNAs and TACs in E. coli at 90 min. ssDNA: single-stranded DNA. Reprinted with permission from Ref. [60]