Fig. 7
From: Tetrahedral framework nucleic acids for improving wound healing
Angiogenesis-promoting effects of tFNAs. (A) tFNAs promote endothelial cell proliferation, migration, and angiogenesis via the Notch signaling pathway. TDN: tetrahedral DNA nanostructures. Reprinted with permission from Ref. [136]. (B) TDNs promoted tube formation of endothelial cells (ECs). Reprinted with permission from Ref. [136]. (C) Measurement of master junctions and master segments; Reprinted with permission from Ref. [136]. (D) Schematic diagram of the antioxidative and angiogenesis-promoting effects of tFNAs in diabetic wound healing. Reprinted with permission from Ref. [72]. (E) Tube formation assay. AGEs: advanced glycation end products. Reprinted with permission from Ref. [72]. (F) Semiquantification analysis of the major junctions and lengths of formed vessels. Reprinted with permission from Ref. [72]