Fig. 8
From: Tetrahedral framework nucleic acids for improving wound healing
Angiogenesis-promoting effects of tFNAs. (A) Angiogenic aptamer-modified tFNAs promote angiogenesis in vitro and in vivo. Reprinted with permission from Ref. [124]. (B) Tube-formation assay for evaluating vascularization after treatment with nanoparticles. VEGF: Vascular endothelial growth factor. Reprinted with permission from Ref. [124]. (C) Cellular uptake of FAM-labeled peptides and FAM-labeled p@tFNA. Reprinted with permission from Ref. [74]. (D) Tube formation assay. p@tFNAs: tetrahedral framework nucleic acid (tFNA)-based peptide. AGEs: advanced glycation end products. Reprinted with permission from Ref. [74]. (E) Analysis of tube nodes, junctions, meshes, total meshes area, branching lengths and branching intervals of formed vessels. p@tFNAs: tetrahedral framework nucleic acid (tFNA)-based peptide; AGEs: advanced glycation end products. Reprinted with permission from Ref. [74]