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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Nitric oxide nano-reactor DNMF/PLGA enables tumor vascular microenvironment and chemo-hyperthermia synergetic therapy

Fig. 4

Mechanistic analysis of DNMF/PLGA NPs in combined therapy. A Heatmap of the SDEGs associated with the VEGF signaling pathway and apoptosis-related pathways. A warm orange color indicates significantly upregulated genes, while a cold blue color represents remarkably downregulated genes. B The volcano plot of SDEGs between the control and DNMF/PLGA NPs + laser groups. Red dots represent upregulated genes, while green dots represent downregulation genes. C The number of SDEGs between the control and DNMF/PLGA NPs + laser groups. D The KEGG enrichment pathway analysis of SDEGs (fold change ≥ 2.0 (or − 2.0) and P < 0.05)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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