Fig. 4

In vivo antitumor efficacy of NanoBE. (a) Mean tumor growth curves of KPC tumors with different treatments (n = 10 each group). Data are presented as mean ± SEM. (b) Kaplan-Meier survival curves of mice in the different treatment groups (n = 10 each group). (c) Individual tumor growth curves of KPC tumors in each treatment group (n = 10 each group). (d) TUNEL staining of apoptotic cells in the KPC tumors. (n = 3 independent mice in different treatment groups) Green, TUNEL; Blue, nucleus. Scale bar = 50 μm. Statistical analysis between the indicated groups was performed using two-way (a) or log rank (Mantel-Cox) test (b) or one-way ANOVA with Tukey’s multiple comparisons test (d). ^***p < 0.001, ^****p < 0.0001