Fig. 6
From: Recent advances in nanomaterial-driven strategies for diagnosis and therapy of vascular anomalies
Copyright 2021, American Chemical Society
Targeting nanoparticles to bioengineered human vascular networks. A Schematic of light-triggered nanoparticles. B TEM image of NP-[CPP]-Alexa. Scale bar: 50 nm; C Fluorescence emission spectrum of NP-[CPP]-Alexa or Alexa-647 fluorophore in PBS with and without irradiation (hν) for 1 min. D Cumulative doxorubicin release from nanoparticles with or without irradiation. E Phototargeting of nanoparticles in vivo in the hVN model. Total radiant efficiency (TRE) in hVN 24 h after IV injection. F Ratio of total radiant efficiency (TRE, per gram of tissue) in the hVNs to TRE (per gram of tissue) in various other organs, in the presence (red) and absence (black) of irradiation.