Fig. 1

Prescription Optimization of Aβ11/T80@CSs. A Schematic diagram illustrating the preparation of PLGA nanoparticles (NPs). This figure shows the particle size (B), zeta potential (C), encapsulation efficiency (D), and brain distribution (E) of PLGA NPs synthesized from various polymer materials. F Schematic diagram depicting the preparation process of Aβ11/T80@CSs. The brain distribution of core–shell nanoparticles modified with varying concentrations of Aβ11 was evaluated (G) and quantified (H). Similarly, the brain distribution of core–shell nanoparticles modified with different amounts of Tween 80 was assessed (I) and quantified (J). All data are expressed as the mean ± standard deviation (SD), with n = 3 independent experiments. Statistical analysis was conducted using a t-test for panels E, H, and J, with significance levels indicated as follows: *p < 0.1, **p < 0.01, ***p < 0.001, ****p < 0.0001