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Table 3 Pharmacokinetic parameters after intravenous injection in rats

From: Dual-targeting tigecycline nanoparticles for treating intracranial infections caused by multidrug-resistant Acinetobacter baumannii

Pharmacokinetic

Unit

Free-TGC

CSs-TGC

Aβ11/T80@CSs-TGC

Cmax

ÎĽg/mL

3.70 ± 0.62

8.09 ± 0.35**

10.72 ± 2.26***

Tmax

h

0.25

0.25

0.25

AUC(0-t)

ÎĽg/mL*h

8.48 ± 2.90

16.51 ± 0.09*

21.62 ± 1.79**

T1/2

h

0.77 ± 0.24

0.91 ± 0.21

1.26 ± 0.21

MRT(0-t)

h

2.6 ± 0.16

2.29 ± 0.10

2.39 ± 0.14

CL

L/h/kg

1.20 ± 0.25

0.59 ± 0.03

0.43 ± 0.02

  1. (x̅ ± SD, n = 3, compared with Free-TGC, *p < 0.5, **p < 0.01, ***p < 0.001)
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Journal of Nanobiotechnology

ISSN: 1477-3155

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