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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Microneedles loaded with cerium-manganese oxide nanoparticles for targeting macrophages in the treatment of rheumatoid arthritis

Fig. 5

Therapeutic effect of the MNs in vivo. (a) Schematic illustration of the CIA mouse model establishment and treatment protocol. (b) Representative macroscopic hind paw images of each group after different formulations. (c) The average of hind paw thickness in mice on day 50. (d) Changes of hind paw thickness and arthritis scores in mice after different treatments. (e) The average of arthritis scores in mice on day 50. (f) Flow cytometry showed the percentage of F4/80+CD206+ M2 in F4/80+ macrophages in liver of CIA mice after different treatments. (g) Representative flow cytometric plots indicated the percentage of CD3+CD4+IL-17 A+ Th17 in spleen of CIA mice after different treatments. (h) ELISA measured cytokines levels in the serum of mice after different treatments. Data were expressed as the mean ± SEM (n = 6, *p < 0.05, **p < 0.01, ***p < 0.001)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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