Fig. 10
Effect of OXA@Fn on immune microenvironment in orthotopic TMZ-resistant glioma tissue. A M1 type GAM (Iba-1 and CD86 co-positive cells) and M2 type GAM (Iba-1 and CD206 co-positive cells) in orthotopic TMZ-resistant glioma tissue. B Typical flow cytometric graph of M1 type and M2 type GAM in orthotopic TMZ-resistant glioma tissue. C CRT and HMGB1 contents in orthotopic TMZ-resistant glioma tissue detected by western blot. D, E The HMGB1 and ATP contents in orthotopic TMZ-resistant glioma tissue. F Typical flow cytometric graph of the matured DC cells, Teff cells (CD3+CD8+IFN-γ+ T cells) and Treg cells (CD4+CD25+FoxP3+ T cells). G The ratio of Treg/Teff cells in orthotopic TMZ-resistant glioma tissue. H–K The content of TNF-α, IFN-γ, IL-12 and IL-10 in orthotopic TMZ-resistant glioma tissues. (n = 3, mean ± SD, *P < 0.05, **P < 0.01)