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Scheme 1 | Journal of Nanobiotechnology

Scheme 1

From: Glioma-targeted oxaliplatin/ferritin clathrate reversing the immunosuppressive microenvironment through hijacking Fe2+ and boosting Fenton reaction

Scheme 1

OXA@Fn crossed BBB and was specifically taken up by TMZ-resistant glioma cells through TfR1. H2O2 induced by OXA reacted with Fe2+ released by Fn to enhance the Fenton reaction, which subsequently boosted the apoptosis and ferroptosis of TMZ-resistant glioma cells and induced a strong T cell mediated anti-cancer immune response to inhibit the growth and invasion of TMZ-resistant glioma

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Journal of Nanobiotechnology

ISSN: 1477-3155

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