Table 2 Immunocyte-derived exosomes for neurotrauma therapy
From: Non-stem cell-derived exosomes: a novel therapeutics for neurotrauma
Study | Source of Exosomes | Animal Model | Trauma Model | Administration | Exosomes modification | Proposed mechanism | Refs |
|---|---|---|---|---|---|---|---|
Li, et al. | Microglia | Mouse | SCI | IV | mRNA-151-3p | Attenuating neuronal apoptosis | [81] |
Li, et al. | Microglia | Mouse | TBI | IV | miR-214-3p | Inhibiting neuronal autophagy | [82] |
Peng, et al. | Microglia | Mouse | SCI | IV | - | Inhibiting oxidative stress and promoting the survival and function of endothelia cells | [83] |
Zhou, et al. | Microglia | Mouse | SCI | IV | miR-672-5p | Inhibiting and neuronal pyroptosis | [84] |
Fan, et al. | Microglia | Rat | SCI | IV | Resveratrol | Activating autophagy and inhibiting apoptosis | [85] |
Zhang, et al. | Peripheral Macrophage | Rat | SCI | IV | - | Activation of microglial autophagy and enhancing the polarization of anti-inflammatory type microglia | [89] |
Luo, et al. | M2 Macrophage | Mouse | SCI | IV | OTULIN protein | Modulating vascular regeneration and neurological functional recovery | [90] |
Huang, et al. | M2 Macrophage | Rat | SCI | IV | - | Improve angiogenesis | [91] |
Zeng, et al. | M2 Macrophage | Rat | SCI | IV | IKVAV peptides | Reducing infiltration of Macrophages, downregulating pro-inflammatory factors | [92] |
Gao,et al. | M2 Macrophage | Rat | SCI | IV | Berberine | Anti-inflammatory | [93] |
Zhang,et al. | M2 Macrophage | Mouse | SCI | LI | Nerve growth factor (NGF), Curcumin (Cur) | Anti-inflammatory | [94] |