Table 3 Vascular-related exosomes and neurotrauma therapy
From: Non-stem cell-derived exosomes: a novel therapeutics for neurotrauma
Study | Source of Exosomes | Animal Model | Trauma Model | Administration | Exosomes modification | Proposed mechanism | Refs |
|---|---|---|---|---|---|---|---|
Pan, et al. | Endothelial progenitor cells | Vitro | - | - | - | Ameliorating neuronal apoptosis | [100] |
Ma, et al. | Endothelial progenitor cells | Vitro | - | - | miR − 210 | Improving mitochondrial function | [101] |
Yerrapragada et al. | Endothelial Progenitor cells | Vitro | - | - | miR − 210 | Enhancing the protective effects on neuron apoptosis, oxidative stress, and decreased viability. | [102] |
Li, et al. | Endothelial Progenitor cells | Vitro | - | - | miR-317 | Boosts the neuroprotective effects of Againsting apoptosis and mitochondrial dysfunction | [103] |
Ge, et al. | Microvascular endothelial cells | Mouse | SCI | IV | USP13 | Regulating immune microenvironment | [106] |
Gao, et al. | Endothelial colony-forming cell | Mouse | TBI | IV | - | Beneficial effects on BBB integrity | [107] |
Yuan, et al. | Pericytes | Mouse | SCI | IV | - | Improve Microcirculation and Protect BBB | [110] |