Fig. 1
Schematic of the design, structure, and therapeutic process of PTMH for impaired wound healing. (A) A dual-layer hydrogel with sodium alginate (SA)-loaded zinc oxide (ZnO) nanoparticles and poly(N-isopropylacrylamide) (PNIPAM)-loaded Cu5.4O ultrasmall nanozymes was designed. (B) The programmed regulation process in the mouse model of diabetic wounds with P. aeruginosa infection, including anti-infection with ZnO via generation of reactive oxygen species (ROS) and anti-inflammation, as well as angiogenesis promotion by Cu5.4O ultrasmall nanozymes. PTMH, programmed time-released multifunctional hydrogel