Fig. 3

Hypoxic tumor model selection, biocompatibility, and uptake of Bi₂S₃/Ti₃C₂-TPP. The GSEA of hypoxia-related genes performed in a TCGA and b CGGA. The enrichment of hypoxia-related gene scores in gliomas of different grades in c TCGA and d CGGA; ****P < 0.0001. The relationship between hypoxia-related gene scores and patient survival time in e TCGA and f CGGA. g Cell viabilities of U251, A172, and HUVEC cells incubated with Bi₂S₃/Ti₃C₂-TPP at various concentrations. h Hemolysis quantification of erythrocytes at various concentrations of Bi₂S₃/Ti₃C₂-TPP. i The contents of Bi and Ti in U251 cells incubated with Bi₂S₃/Ti₃C₂-TPP measured by ICP-MS; *P < 0.05. j The image of Mito-Tracker Red stained U251 cells treated with Bi₂S₃/Ti₃C₂-TPP (100 µg mL^-1, scale bar = 20 μm)