Fig. 2
T1-weighted MRI performance and characterizations for Gd-HPMA macrochelates. A, B: The black & white and corresponding pseudo-color T1-weighted MR images of Gd-HPMA12 macrochelate atd 3.0 T A or 7.0 T B compared with Magnevist®, Gadavist® and pure water. C, D: ΔSNR of the MR images A, B for Gd-HPMA12 compared with Magnevist® or Gadavist® at 3.0 T C or 7.0 T D. ****P < 0.0001. E: FT-IR spectra of HPMA and Gd-HPMA12. F: Field-dependent magnetization curve of Gd-HPMA12 measured by physical property measurement system (PPMS) at 300 K. G: The time-dependent release of free Gd3+ from Magnevist®, Gadavist®, Gd-HPMA12 in DMEM with 10% FBS, or saline solution of pH 2.0, pH 7.0, or pH 7.0 with double amount of Zn2+ compared with Gd in Gd-HPMA12