Fig. 2
From: Multifunctional fucoidan-loaded Zn-MOF-encapsulated microneedles for MRSA-infected wound healing
Characterization and antibacterial activity of free Fu, ZIF NPs and Fu-loaded NPs. (A) SEM images (scale bar: 500 nm, 200 nm in inset images). (B) TEM elemental mappings of HAZ@Fu. (C) The size distribution, (D) zeta potential, and (E) XRD patterns of Zn-MOF derived nanoparticles. (F) FTIR spectra of Fu, crude Fu, ZIF and ZIF@Fu. (G) FTIR spectra of HA, ZIF and HAZ. (H) The release curve of Zn2+ derived from the decomposition of ZIF NPs in solution at pH = 7.4 or 5.0 (inset: standard curve of zinc ions). (I) MRSA cells (1 × 106 CFU/mL) resuspended in PBS were incubated with crude Fu, Fu, ZIF and ZIF@Fu in vitro for 16 h, serially diluted 100-fold with PBS, inoculated onto LB agar plates, then incubated for another 24 h. (J) ZOI test of Crude Fu, Fu, ZIF and ZIF@Fu against MRSA