Table 1 Pharmacokinetic parameters of DEX solution, DEX NEs, and DEX 10% SC-NEs after topical instillation in rabbits (n = 3)
From: OCTN2- and ATB0,+-targeted nanoemulsions for improving ocular drug delivery
Ocular tissues | Pharmacokinetic parameter | DEX solution | DEX NEs | DEX 10% SC-NEs |
|---|---|---|---|---|
Cornea | AUC(0-∞) (μg/g·min) | 39.70 ± 3.66 | 101.35 ± 4.49* | 204.06 ± 18.42*, # |
Cmax (μg/g) | 1.00 ± 0.17 | 3.40 ± 0.26* | 6.43 ± 0.60*,# | |
Aqueous humor | AUC(0-∞) (μg/mL·min) | 33.05 ± 1.87 | 43.10 ± 2.57* | 54.76 ± 2.95*, # |
Cmax (μg/mL) | 0.27 ± 0.02 | 0.43 ± 0.03* | 0.56 ± 0.01*, # |