Fig. 4
From: The development of a novel zeolite-based assay for efficient and deep plasma proteomic profiling
Characterization of the plasma proteome recovered by M086. A Volcano plot showing the annotation enrichment analysis for functional pathways (GOCC, GOBP, GOMF, KEGG, Uniports Keywords, Pfam, and SMART) of proteins detected by using M086 compared to those in the HPA database. B 1D annotation enrichment analysis comparing the protein intensity distribution (median intensity across assay triplicates, requiring three out of three quantifications) of each method to the average of all methods. C Matching of M086-recovered, depleted plasma and neat plasma samples to the HPA included & FDA approved biomarkers. Ranked intensities for all proteins detected by at least one method are shown in the top panel (combined). D Comparison of M086-recovered, depleted plasma and neat plasma samples with the Open Targets database. The rank average score for all proteins detected by at least one method is shown in the top panel (combined). E The radar plot shows the performance of M086-recovered, depleted plasma and neat plasma analysis in identifying tumours (breast, liver, gastric, colorectal and lung cancer), chronic diseases (type 2 diabetes and HBV infection) and acute diseases (COVID-19 infection and acute myocardial infarction).