Fig. 5
From: The development of a novel zeolite-based assay for efficient and deep plasma proteomic profiling
Application of M086-based plasma proteomics in an HCC cohort. A Principal component analysis (PCA) showing significant differences between the healthy population group (blue) and the HCC patient group (red). B Heatmap showing that healthy individuals (orange), patients with early-stage HCC (brownish yellow) and patients with intermediate-stage to advanced HCC (red) have different proteomic characteristics. The heatmap on the top right shows the top 50 differentially expressed proteins (ranked by adjusted P values), and the heatmap on the bottom right shows the proteins that showed a consistent trend among the three groups. All protein expression values were transformed by the Z score. C GO and KEGG enrichment results of the differentially expressed genes between patients with HCC and healthy individuals. D UpSet plot showing the overlap between biomarkers detected by M086 and those detected in previous studies. E The left panel shows the performance of 15 selected markers in HCC diagnosis; the right panel shows the VIP scores and the Open Targets scores for 15 selected markers