Intranasal delivery of phenytoin loaded layered double hydroxide nanoparticles improves therapeutic effect on epileptic seizures

Zhang, Jingxin; Zuo, Huali; Fu, Yanlu; Cao, Yina; Li, Qiwei; Zhang, Qi; Zheng, Yuyi; Wang, Yi; Wu, Di; Chen, Weiyu; Fang, Jiajia

doi:10.1186/s12951-024-02405-8

Fig. 2

From: Intranasal delivery of phenytoin loaded layered double hydroxide nanoparticles improves therapeutic effect on epileptic seizures

Characterization of BSA-LDHs-PHT. a Schematic diagram of the composition of BSA-LDHs-PHT. b, c TEM micrographs of BSA-LDHs and BSA-LDHs-PHT. d The drug adsorption rate increases as the mass ratio of PHT/BSA-LDHs increases from 1:2 to 1:6. e, f The profile analyzed by DLS shows the average size and zeta potential of LDHs, BSA-LDHs, and BSA-LDHs-PHT. g The colloidal stability of LDHs, BSA-LDHs, and BSA-LDHs-PHT in water and FBS for 24 h. h XRD patterns of LDHs, BSA-LDHs, and BSA-LDHs-PHT. i FTIR analysis of BSA-LDHs-PHT. j PHT was progressively released from the nanoparticles, reaching 36.91 ± 2.07% of the initially encapsulated drug within 24 h. The data presented were the mean ± SD (n = 3)

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Fig. 2

Journal of Nanobiotechnology

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