Intranasal delivery of phenytoin loaded layered double hydroxide nanoparticles improves therapeutic effect on epileptic seizures

Zhang, Jingxin; Zuo, Huali; Fu, Yanlu; Cao, Yina; Li, Qiwei; Zhang, Qi; Zheng, Yuyi; Wang, Yi; Wu, Di; Chen, Weiyu; Fang, Jiajia

doi:10.1186/s12951-024-02405-8

Fig. 5

From: Intranasal delivery of phenytoin loaded layered double hydroxide nanoparticles improves therapeutic effect on epileptic seizures

Epileptic seizure control of BSA-LDHs-PHT I.N. delivery. a Schematic diagram of PTZ-induced acute seizures after 5 and 30 min of administration. b The representative EEGs of normal mice and epileptic mice at stage 2, 4, and 6. c Statistics of the latency of I.N., PHT oral, PHT I.N., and BSA-LDHs-PHT I.N. after 5 min of administration. d Statistics of the latency of I.N., PHT oral, PHT I.N., and BSA-LDHs-PHT I.N. after 30 min of administration. Data expressed as mean ± sem (n = 10). * p < 0.05; ** p < 0.01; *** p < 0.001. NP nanoparticle, IN intranasal

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Fig. 5

Journal of Nanobiotechnology

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