Intranasal delivery of phenytoin loaded layered double hydroxide nanoparticles improves therapeutic effect on epileptic seizures

Zhang, Jingxin; Zuo, Huali; Fu, Yanlu; Cao, Yina; Li, Qiwei; Zhang, Qi; Zheng, Yuyi; Wang, Yi; Wu, Di; Chen, Weiyu; Fang, Jiajia

doi:10.1186/s12951-024-02405-8

Fig. 6

From: Intranasal delivery of phenytoin loaded layered double hydroxide nanoparticles improves therapeutic effect on epileptic seizures

Toxicity assessment of BSA-LDHs-PHT. a Daily weight changes during administration in mice. b, c Histopathological evaluation of major organs (brain, heart, liver, and kidneys) (b) and mice nasal mucosa (c) was performed after a 7-day repeated dose study. d Blood routine (RBC, WBC, PLT) of two groups of mice after 7 days of administration. e Renal function (blood urea nitrogen, creatinine, uric acid) of two groups of mice after 7 days of administration. f Liver function (Direct bilirubin, albumin, ALT) of two groups of mice after 7 days of administration. Data expressed as mean ± sem (n = 4). * p < 0.05; ** p < 0.01; *** p < 0.001

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Fig. 6

Journal of Nanobiotechnology

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