Fig. 15
From: Neuromodulation by nanozymes and ultrasound during Alzheimer’s disease management
Left panel. Scheme Aβ pathways influenced by AuNPs@POMD-8pep. A Synthetic route of the nanozyme. B AuNPs@POMD-8pep acted as a multifunctional nanozyme to modulate multiple facets of Alzheimer’s disease; Right panel. Working principle and cleavage sites of AuNPs@POMD8pep on Aβ40. A Mulliken charge distributions for the Ser190 hydroxyl group in native protease, and B the oxygen groups of POM in the nanozyme. The purple arrow in (B) Illustrates the electronegative oxygen groups of POM attacking the electropositive carbon atom in the peptide bond. C Cleavage sites of the most important Aβ-degrading enzymes on Aβ40. D Cleavage sites of AuNPs@POMD-8pep on Aβ40. More red arrows are assigned to the sites appearing earlier in the analysis. Reproduced with permission copyright 2016, Springer [151]