Fig. 16
From: Neuromodulation by nanozymes and ultrasound during Alzheimer’s disease management
Left panel. Schematic of the present study. In the presence of extracranial US, Qc@SNPs-MB is destroyed to form Qc@SNPs, which has increased BBB permeability. After crossing the BBB, Qc@SNPs is taken up by neurons and reduce the intracellular ER stress, and the apoptosis, inflammation, homeostasis of calcium ions and oxidative stress induced by ER stress; Right panel. BBB permeability of NPs. A Opening of the BBB was assessed using Evans blue. B Change in the TEER value of the bEnd.3 cell monolayer. C In vivo fluorescence images of mice given Qc@SNPs by direct injection, Qc@SNPs-MB by direct injection and Qc@SNPS-MB + US. D Fluorescence intensity at different times in the brain of the mice. The data are presented as mean ± standard deviation (n = 3). The labels *, **, and *** indicate p < 0.05, p < 0.01, and p < 0.001, respectively, compared with the control group and Qc@SNPs direct inject group. E Confocal fluorescence images of the mice parietal cortex. Reproduced with permission copyright 2020, Royal Chemical Society [158]