Fig. 7
From: Neuromodulation by nanozymes and ultrasound during Alzheimer’s disease management
Brain-targeted delivery of US-HA-Exo combined with FUS-mediated BBB opening. A, B Schematic of FUS-BBB opening-assisted delivery of exosomes. C Brain sections obtained from 10-month-old APP/PS1 mice were immuno-stained for Aβ, scale bar: 100 µm. D The percentage area of positive amyloid-β stainning was quantified. E, F Aβ plaques in the brain were detected by thioflavin-S staining (scale bar: 100 µm), and quantified. G H&E staining of major organs of mice, scale bar: 100 µm [113]. Reproduced with permission copyright 2021, Ivyspring International Publisher