Fig. 5
From: Smart osteoclasts targeted nanomedicine based on amorphous CaCO3 for effective osteoporosis reversal
OAPLG effectively reduces bone loss from OVX. (a) Schematic illustration of the arrangement of animal experiments to assess the anti-osteoporosis potential of OAPLG. (b) H&E staining of major organs, scale bar 100 μm. (c) Representative Micro-CT images of the distal femur transverse section, longitudinal section and ROI reconstructed trabecular structure collected from ovariectomized mice treated with ORO, APLG, OAPL, OAPLG and the untreated control group. (d) BMD; (e) BV/TV; (f) Tb. Th; (g) Tb. N; (h) Tb. Sp. n = 3, *P < 0.05, **P < 0.01, ***P < 0.001; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. Sham