Fig. 1

Schematic of miR-26a-5p nanoparticle targeted delivery system and long-lasting analgesia through anti-inflammation. A Mesoporous silica nanoparticles modified with MG1-targeting peptide and loaded with miR-26a-5p which targeted Wnt5a. B miR-26a-5p nanoparticle targeted delivery system provides long-lasting analgesia. C MG1 modification increases nanoparticle enrichment in microglia and efficiently regulate neuroinflammation. (A: Ethanol APTES, MSN: Mesoporous silica nanoparticle)