Fig. 3

Physicochemical characterization and cytocompatibility testing of nanoparticles. A Standard curve for targeting peptide MG1 (absorbance—concentration). B Variation of targeting peptide MG1 concentration in solution with time of chemical grafting reaction. C Standard curve of miR (absorbance-concentration). D Concentration changes during the loading of miR into nanoparticles in solution. E In vitro simulation of miR release profile (release ratio–time). F Thermogravimetric analysis of A-MSN, A-MSN-MG1. G Fourier transform infrared (FTUR) spectra of MSN, A-MSN and A-MSN-MG1. H Toxicity test for cell proliferation viability of MSN, A-MSN, A-MSN-MG1 and miR@ A-MSN-MG1 (CCK-8). I Cytotoxicity experiments of MSN, A-MSN, A-MSN-MG1 and miR@ A-MSN-MG1 (live-dead staining)