Fig. 3
A Cellular uptake and localization of free DOX, DOX NPs and MM@DOX NPs in SCC15 or HN6 cells were observed by fluorescence microscopy after incubation of 1, 3 and 5 h, respectively. B The flow cytometry profiles incubated with varied treatments in SCC15 for different time intervals and C the corresponding quantitative analysis of mean fluorescence intensity (n = 3, mean ± SD, * p < 0.05, *** p < 0.001). D The flow cytometry profiles incubated with varied treatments in HN6 for different time intervals and E the corresponding quantitative analysis of mean fluorescence intensity (n = 3, mean ± SD, *** p < 0.001)