Fig. 2

In vitro anti-tumor effect of HPNDs@EcN. (A) Schematic diagram of ultrasound mediated-SDT for tumor therapy. (B) HMME released from HPNDs@EcN with and without ultrasound treatment. (C) HMME intracellular uptake: Red: HMME; Blue: DAPI staining (scale bar: 20 μm). (D-E) Intracellular reactive oxygen production detection and quantification. (F-G) Cell cytotoxic qualitative and quantitative analysis with live dead double staining and CCK 8 assay. (** p < 0.01, **** p < 0.0001)