Fig. 5

In vivo therapeutic effects of Bm@PT/Enz-miR26a in two models. (A–B) Tumor volume growth in subcutaneous CRPC and BmCRPC mouse models over 12 days. n = 5, mean ± SD, **p < 0.01, ***p < 0.001, ****p < 0.0001, one-way ANOVA. (C–D) Tumor weight growth in subcutaneous CRPC and BmCRPC mouse models. n = 5, mean ± SD, ****p < 0.0001, one-way ANOVA. (E–F) Body weight growth in subcutaneous CRPC and BmCRPC mouse models over 12 days. n = 5, mean ± SD. (G–H) Survival time of tumor-bearing mice in subcutaneous CRPC and BmCRPC mouse models. n = 5, mean ± SD, ****p < 0.0001, one-way ANOVA. (I–J) TUNEL assay was performed to evaluate the apoptosis of tumor cells in subcutaneous CRPC and BmCRPC mouse models. TUNEL: green, Scale bar: 50 μm