Fig. 2

The antioxidation and pancreas-targeting property of DTP@KA NPs. A. Representative Hoechst33342/PI staining images of primary PAC after 100 μM H₂O₂ administration. Scar bar = 50 μm. B Viabilities of primary PAC co-incubated with different concentrations of DTP@KA NPs for 0 h, 6 h, 24 h and 48 h. C Glutathione (GSH)/oxidized glutathione (GSSG) ratio in primary PAC under DTP@KA NPs treatment with different concentrations. D, E In vitro DIR fuorescence images D and quantitative analysis E of pancreas from SAP model mice treated with DTP@KA NPs for 24 h. Data represent the mean ± SEM of at least three independent experiments; n = 5–8/group. Significance: ^#p < 0.05 vs 0 h. ^* p < 0.05, ^** p < 0.01 and ^*** p < 0.001 vs. the DP@KA NPs groups