Fig. 6

DTP@KA NPs improved mitochondrial fission by activating TOM20-STAT6 signaling pathway. A. Protein expressions of STAT6, TOM20 and Drp1 in pancreas lysate. B. Quantitative analysis of STAT6, TOM20 and Drp1 protein expressions. C. Distributions and expressions of STAT6 and TOM20 in pancreas tissues. Scar bar = 20 μm. D. Co-localization and expressions of TOM20 and STAT6 with IF staining in pancreas tissues. Scar bar = 50 μm. E. IHC staining of Drp1 and Bax in pancreas tissues. Scar bar = 20 μm. Data represent the mean ± SEM of at least three independent experiments; n = 5–8/group. Significance: ^* p < 0.05 and ^**p < 0.01 vs. the control group; ^# p < 0.05, ^## p < 0.01 vs. the SAP model group