Fig. 4
FerOX production and antitumor activity compared to DOX and Myocet. A Schematic representation of FerOX production. HFn nanocages have been loaded with DOX following the pH-dependent disassembly/reassembly procedure. B IC50 of PDO treated with FerOX, DOX and Myocet. PDO’s viability data used to calculate IC50 have been obtained by Cell titer Glo assay. Statistical significance: **p < 0.01, ***p < 0.005 (Two-way ANOVA). C Correlation between FerOX IC50 and TfR1 expression of each PDO (r2 = 0.3701; r = − 0.6083; p = 0.0310). TfR1 expression has been determined as mean MFI evaluated by flow cytometry