Fig. 8

a Hematoxylin and eosin (H&E) staining of major organs in healthy rats after various treatments. b Blood routine analysis of SD rats after various treatments. c-f Blood coagulation parameters (PT, aPTT, TT, FIB) in rat plasma after various treatments. n = 6, mean ± SD. Scale bar = 100 μm. G0, Control group; G1, Sham model group; G2, Model group; G3, Free ICG (0.35 mg·kg^− 1) + NIR group; G4, TPNs/ICG-PEG (7.8 mg·kg^− 1) + NIR group; G5, TPNs/ICG-cRGD (7.8 mg·kg^− 1) + NIR group; WBC, white blood cell; Lymph, lymphocyte; Mon, monocyte; Gran, granulocyte; RBC, red blood cell; HGB, hemoglobin; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; RDW, red blood cell volume distribution width; PLT, platelet count; MPV, mean platelet volume; PDW, platelet distribution width; PT, prothrombin time; aPTT, activated partial thrombin time; TT, thrombin time; FIB, Fibrinogen