Fig. 8
GNPs treatment changed the profile of SCFA metabolism in ACLT-induced OA mice. (A) Heatmap of SCFAs between ACLTVehicle and ACLTGNPs groups. The blue indicates lower abundance and red indicates higher abundance. (B) The concentration of SCFAs including valeric acid, propionic acid, acetic acid, butyric acid, decanoic acid, hexanoic acid, isobutyric acid, isovaleric acid, nonanoic acid, and octanoic acid from feces between ACLTVehicle and ACLTGNPs mice. (C) Correlation analysis between SCFAs and femur-related indexes. Colorings represent the median Spearman correlation coefficient. (D) Correlation analysis between SCFAs and tibia-related indexes. Colorings represent the median Spearman correlation coefficient. (E) Correlation analysis between SCFAs and gut microbiota at genus taxonomic level. Colorings represent the median Spearman correlation coefficient. n = 7 samples per group. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, N.S represented not significant)