Fig. 6

In Vivo Anti-Tumor Efficacy and Biosafety of SFN/BQR1@MSPION3. Anticancer efficacy measured on 4T1 tumor-bearing mice treated with PBS (I), MSPION3 (II), SFN1@MSPION3 (III), BQR1@MSPION3 (IV), and SFN/BQR1@MSPION3 (V) by intravenous injection on day 0 and 7. Fe dosage = 5.0 mg/kg. a, Schematic illustration of in vivo therapy for 4T1 subcutaneous tumor-bearing mice. b, d, The tumor growth curves (b), survival curves (c), and body weights (d) of 4T1 tumor-bearing mice from each group (n = 5). e, Representative optical microscopic pictures of sectioned tumor tissue (scale bar: 100 μm) from the five groups of 4T1 tumor-bearing mice after HE, Ki67, TUNEL, GPX4, or LPO staining. **P < 0.01