Circulating tumor cell-derived exosome–transmitted long non-coding RNA TTN-AS1 can promote the proliferation and migration of cholangiocarcinoma cells

Zhou, Xu; Kong, Xiaohan; Lu, Jun; Wang, Heng; Liu, Meng; Zhao, Shuchao; Xia, Zhaozhi; Liu, Qinggong; Sun, Hongrui; Gao, Xin; Ma, Chaoqun; Niu, Zheyu; Yang, Faji; Song, Xie; Gao, Hengjun; Zhang, Shizhe; Zhu, Huaqiang

doi:10.1186/s12951-024-02459-8

Fig. 6

From: Circulating tumor cell-derived exosome–transmitted long non-coding RNA TTN-AS1 can promote the proliferation and migration of cholangiocarcinoma cells

The effect of exosomes secreted by cholangiocarcinoma CTCs-organoids on the proliferation and migration of Huh28 cells. (A) Significant upregulation of TTN-AS1 expression in Huh28 cells co-cultured with CTCs-exosomes; (B) CTCs-exosomes promote the growth of Huh28 cells; (C) CTCs-exosomes enhance the clonogenicity of Huh28 cells; (D) CTCs-exosomes increase Cyclin D1 mRNA expression in Huh28 cells; (E) CTCs-exosomes accelerate the cell cycle progression of Huh28 cells; (F) CTCs-exosomes inhibit apoptosis of Huh28 cells; (G) CTCs-exosomes facilitate the migration of Huh28 cells; (H) CTCs-exosomes promote the migration of Huh28 cells; (I) Expression of EMT-related genes in Huh28 cells after co-culture with CTCs-exosomes; (J) Expression of Cyclin D1 and EMT-related proteins in Huh28 cells after co-culture with CTCs-exosomes

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Journal of Nanobiotechnology

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