Fig. 10
From: Developing hydrogels for gene therapy and tissue engineering
Applications of therapeutic gene hydrogels in OA. A Injectable exosome hydrogel for cartilage defect regeneration. (i) Promoting superficial cartilage regeneration; (ii) Repair of cartilage defects by the AD/CS/RSF/EXO hydrogel; (iii) Gross observation of cartilage integrity; (iv) MRI images of rat knees. (Reproduced with permission from Ref. [47], Copyright 2021, Elsevier). B MS@G5-AHP/miR-140 to treat OA. (i) Gene-hydrogel MSs; (ii) Articular cavity injection of MS@G5-AHP/miR-140 to alleviate OA; (iii) Release of miR-140 and endocytosis of G5-AHP/miR-140. (Reproduced with permission from Ref. [161], Copyright 2022, Springer Nature)